A truck driver has been taken to hospital after his B-double truck left the road and tumbled into a creek.

Just before 10am on Thursday, emergency services were called to Nangkita Rd, Nangkita (near Willowburn Drive) on the Fleurieu Peninsula, after reports a cattle truck had rolled.

Police arrived to find the truck down an embankment and in a creek.

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The driver, a 29-year-old man from Craigmore, was taken to hospital with non-life-threatening injuries.

He will undergo mandatory blood tests.

Due to the location of the truck, the number of cattle injured is currently unknown.

A heavy vehicle tow truck is at the scene and PIRSA personnel are in attendance to assist with euthanasia of the animals.

Nangkita Rd is expected to remain closed until 7pm on Thursday and road users are asked to avoid the area.

The investigation into the circumstances of the crash is ongoing.