A motorcyclist has died and his passenger is fighting for life after a crash on Saturday.

Their bike collided with a car at the intersection of Mill Rd and Taylors Rd at Moutajup, 10-minutes south of the Grampians National Park in Victoria, about 4.30pm.

The motorcyclist, a 53-year-old man from Coleraine, died at the scene.

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His passenger, who is yet to be formally identified, was airlifted to hospital with life-threatening injuries.

The driver of the car involved, a 20-year-old man from Lake Mundi man, stopped at the scene. He was not physically injured.

The young man was interveiwed by police pending results of an ongoing investigation.

Any witnesses or anyone with dashcam footage is urged to contact Crime Stoppers.